These early CREB-mediated signaling events predicted that CREB inhibition would lead to enhanced macrophage control of M. tb-induced CREB activation leads to expression of immediate early genes including COX2, MCL-1, CCL8 and c-FOS, as well as inhibition of NF-kB p65 nuclear localization. Using a CREB-specific inhibitor, we determined that M. tb-induced CREB activation is dependent on signaling through MAPK p38 in human monocyte-derived macrophages (MDMs). However, the mechanism(s) underlying CREB activation and its downstream roles in human macrophage responses to M. tb rapidly activates cAMP Response Element Binding Protein (CREB), a transcription factor that regulates diverse cellular responses in macrophages. tb) is a human-adapted intracellular pathogen that exploits macrophages as an intracellular niche. However, certain invading microbes modify macrophage responses to promote their own survival and growth. Macrophages are a first line of defense against pathogens.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |